Open Government Highlights: 1000 points of data

Kenneth Duberstein, who was the White House Chief of Staff from 1988-1989 had a very interesting Op-Ed piece in the New York Times Feb 23 (Op-Ed Contributor - 1,000 Points of Data - NYTimes.com). In it he calls for the US Government to allow for all citizens to assess the State of the Union themselves:
What we need now is a Web-based system for measuring our changing society with key national indicators — in a free, public, easy-to-use form. Ideally, it would be run by the nonpartisan National Academy of Sciences, which would ensure it has the best quality of information and is kept up to date. The system would enable us to offer in one place statistical information that we spend billions of dollars collecting but that is now underused and undervalued.
Noting that this idea is possibly going to be a reality, he writes:
Senators Edward M. Kennedy, Democrat of Massachusetts, and Michael Enzi, Republican of Wyoming, plan to soon introduce a bill that would allocate about $7.5 million a year for such a comprehensive database of key national indicators, and the idea already has wide bipartisan support.
Duberstein further states
Great steps forward in American history occur at moments when our deeply held values are reaffirmed in the face of changing realities. Such a moment is at hand. We need a shared frame of reference that will enable us to practice collective accountability.
I think this is a stellar idea. Access to information is critical for our future. Good to see this notion getting more and more support throughout the government.

Darwin in Davis

Since this is kind of a Davis thing too I am cross posting it from my work blog.

Well, this has been a good week for me in Davis in terms of things in which I am interested. First, the Tour of California started in Davis and then tonight we had a Darwin celebration (with cake and talks) in a movie theater in downtown. The three talks were by Rick Grosberg, who gave a good background on Darwin the person, Mau Stanton who talked about Evolution and Society and me, who talked about Uses of Evolution. The shindig was sponsored by the Center for Population Biology and funded by the Storer Endowment. And it was organized by Angus Chandler and Dena Grossenbacher and possibly some others. And the theater was packed to the gills. Food. Folks. And Fun. And I owe some thanks to folks who responded to my FriendFeed posting asking about other examples of Uses of Evolution.

Here are some pics ...




Also see

Darwin Celebration in Davis

Well, this has been a good week for me in Davis in terms of things in which I am interested. First, the Tour of California started in Davis and then tonight we had a Darwin celebration (with cake and talks) in a movie theater in downtown. The three talks were by Rick Grosberg, who gave a good background on Darwin the person, Mau Stanton who talked about Evolution and Society and me, who talked about Uses of Evolution. The shindig was sponsored by the Center for Population Biology and funded by the Storer Endowment. And it was organized by Angus Chandler and Dena Grossenbacher and possibly some others. And the theater was packed to the gills. Food. Folks. And Fun. And I owe some thanks to folks who responded to my FriendFeed posting asking about other examples of Uses of Evolution.

Here are some pics ...




Also see

Bad evolution puns award #1: Cod in the act of evolution

Sure - we are celebrating Darwin this month and through the year. But one negative of evolution in general is that it seems particularly ripe for puns, and bad ones at that. So I am starting a new award here - the Bad Evolution Puns Award. And the first winner is the Boston Globe for their new article "Cod in the act of evolution" by Murray Carpenter.

My favorite evolution stuff 1. 1900 Darwin Post Card

Just starting a new thread here --- my favorite evolution stuff.  And here is one.  It is a post card that I found inside a 1880s version of Origin of Species that I bought at a used book store.  The book was part of a collection from Ellison A. Smith which was being sold at a used book store in Georgetown many years ago.  I bought a bunch of old evolution books and inside many of them were post cards advertising portraits of some of the authors.  Here is one -- advertising a portrait of Darwin.  Wish I had the portrait ...

Is boycotting the right way to deal with anti-evolution sentiment?

Adam Nossiter in the New York Times is reporting that the Society for Integrative and Comparative Biology (SICB) has decided to in essence boycott New Orleans as a site for a future conference. They are doing this in response to a bill passed last year by Louisiana that is considered by many to be a hidden way to introduce religion into scientific teaching (the Times says the bill "allows teachers to “use supplemental textbooks” in the classroom to “help students critique and review scientific theories.”). The SICB wrote a letter to Governor Jindal saying

“It is the firm opinion of S.I.C.B.’s leadership that this law undermines the integrity of science and science education in Louisiana,” 
and
“The S.I.C.B. leadership could not support New Orleans as our meeting venue because of the official position of the state in weakening science education and specifically attacking evolution in science curricula,” “As scientists, it is our responsibility to oppose anti-science initiatives.”


I note that they are going to hold their meeting in Salt Lake City instead, which at least in regard to science evolution and science education and state policy, is a bit better (e.g.,the Utah State Board of Education has made it clear it supports teaching evolution (see here)).

Along with the letter, a group called the Loiuisiana Coalition for Science has issued a press release saying that the state is "reaping what is sowed" by passing the bill.

So the question I have been asking myself is - is a boycott the right thing to do here? I am not sure. On the one hand, I commend SICB for taking a public action that is more than just words. I think it is pretty clear that this bill was designed as a backdoor way to allow religion beliefs to shape what is taught in public school science classes, which is sad. In response to this, I think scientists should do something more than just say this is a bad idea so at least SICB did something.

On the other hand, a boycott is perhaps a bit extreme and comes with many complications. In many cases, engagement is probably a better strategy. It is ironic in a way for a science group to be taking a George Bush-esque approach to dealing with disagreement. I guess I lean away from the boycott step not because it seems completely wrong, but because it seems a bit premature. Perhaps AICB could have held the conference there and organized a series of public discussion about science teaching. And on top of that they could have made a small contribution to a community that has been really hit hard recently.

Boston University adopts Open Access policy

Just saw a nice story about BU adopting an Open Access policy.

See the BU Today article

Some detail with some nice quotes in support of OA:

Boston University took a giant step towards greater access to academic scholarship and research on February 11, when the University Council voted to support an open access system that would make scholarly work of the faculty and staff available online to anyone, for free, as long as the authors are credited and the scholarship is not used for profit.
...
“Open access will really highlight the tremendous productivity of our faculty,” says Millen. “Among the more important things needed to make it work is a collaboration between the libraries and our faculty to get their research onto the Web. It’s not an inconsequential task.”

....
“This vote sends a very strong message of support for open and free exchange of scholarly work,” says Hudson. “Open access means that the results of research and scholarship can be made open and freely accessible to anyone. It really has increased the potential to showcase the research and scholarship of the University in ways that have
not been evident to people.”


Hat tip to Tom Tullius ...

Some pics from the Tour in Davis

Well, it was really really really wet out there but tons of people were out in Davis nevertheless. I got some pics -- although my phone cam was not working great in the pouring rain. Anyway - here they are, including one of Floyd Landis ..




Tour of California before the start in Davis

Here comes the tour (of California) --- Davis is going big ---



Very excited that the Tour of California is starting in Davis this year (for Stage 1 on Sunday). It should be a good stage --- from Davis to Santa Rosa.

And there are many many big names in the tour this year - even more than last year. In particular of course is Lance Armstrong. I have been a big fan of Lance for many many years -- since I encountered him in Palo Alto when I was a grad. student. He had just won the World Championship and was in town to sing autographs and hang out at Wheelsmith, the best bike shop in the area. I was just getting into cycling and was going to Wheelsmith for some other reason and there was Lance. I got him to sign a few things and then thought, what would be coolest would be if he signed my favorite T-shirt (which I am wearing in the picture here). And he made my day by saying "Cool shirt" and asking where I got it.

Anyway --- it is going to be a big big day in Davis tomorrow with Lance Armstrong, and a whole gaggle of big time cyclists here in the best biking town in the country.

And here are some links related to the race ...

NSF looking OK in revised stimulus bill

Just downloaded what I think is the current bill that the House just passed for the stimulus.  And it looks like the National Science Foundation is coming out OK.  It says


NATIONAL SCIENCE FOUNDATION
NSF is directed to submit to the House and Senate Committees on
Appropriations a spending plan, signed by the Director, detailing its intended
allocation offunds provided in this Act within 60 days of enactment of this Act.
RESEARCH AND RELATED ACTIVITIES

For research and related activities, the conference agreement provides a total
of $2,500,000,000, to remain available until September 30,2010. Within this
amount, $300,000,000 shall be available solely for the major research
instrumentation program and $200,000,000 shall be available for activities
authorized by title II of Public Law 100-570 for academic facilities modernization.
In allocating the resources provided under this heading, the conferees direct that
NSF support all research divisions and support advancements in supercomputing
technology.

EDUCATION AND HUMAN RESOURCES
The conference agreement includes $100,000,000 for education and human
resources, to remain available until September 30, 2010. These funds shall be
allocated as follows:
Robert Noyce Scholarship Program .......................... .
Math and Science Partnerships ................................. .
Professional Science Master's Programs .................. .
$60,000,000
25,000,000
15,000,000
MAJOR RESEARCH EQUIPMENT AND FACILITIES CONSTRUCTION
The conference agreement includes $400,000,000 for major research
equipment and facilities construction, to remain available until September 30,
2010.
OFFICE OF INSPECTOR GENERAL
The conference agreement includes $2,000,000 for the Office of Inspector
General, to remain available until SeptemberJO, 2013.


"

Charles Darwin relic hidden in the chimp and human genomes

So - in honor of Charles Darwin and as a follow up to my analysis of Sarah Palin's name (which amazingly showed as a best hit a fungus called B. fuckeliana) I decided today to do some blast searches with old Charlie D.'s name. You see CHARLES DARWIN includes letters that all are abbreviations of amino acids that make up proteins, so you can compare his name, pretending it is a protein, to proteins from other organisms.

So I went to the NCBI blast page and did a BLASTP search. Blastp searches a peptide against a database of peptides and identifies in the database sequences if one or more have similar amino-acid sequences to the one used to search (which is known as the query) . To make this work, I had to adjust some of the default parameters to make it possible to better detect short matches (I raised the # of expected matches to 10000).

Alas, no good matches convincing matches to known or predicted proteins came up. So I was sad. Then I said, what if Darwin was hiden in the genome of some organism? So I did a "translational" blast search called tblastn which takes a peptide and searches it against a DNA database and translates the DNA into all possible peptides it could encode. When one does this, one can possibly find "hidden" proteins or relics of proteins in the DNA that may not have been labelled as proteins by whomever analzyed the DNA data.

And what did I find by this Tblastn search? A jackpot to make evolutionary biologists VERY happy. The best matches for CHARLESDARWIN the peptide? Pan troglodytes. AKA Chimps. And humans (the matches were equally strong).

So - hidden in the human and Chimp genomes is a relic of one Charles Darwin. Happy Birthday Charlie.

----------------------------------------------
See search results below:

Score E
Sequences producing significant alignments: (Bits) Value


gb|AC199643.3| Pan troglodytes BAC clone CH251-444E8 from chr... 25.8 1930
gb|AC093749.3| Homo sapiens BAC clone RP11-30B7 from 4, compl... 25.8 1930
gb|AF250324.1|AF250324 Homo sapiens chromosome 4q35 BAC clone... 25.8 1930
gb|AC217674.3| Pan troglodytes BAC clone CH251-398H5 from chr... 25.0 3549
gb|AC195095.2| Pan troglodytes BAC clone CH251-577A14 from ch... 25.0 3549
gb|AC188794.3| Pan troglodytes BAC clone CH251-69H24 from chr... 25.0 3549
gb|AC183104.3| Pan troglodytes BAC clone CH251-567E15 from ch... 25.0 3549
gb|AF105153.3| Homo sapiens alpha-satellite centromere border... 25.0 3549
emb|AL353763.14| Human DNA sequence from clone RP11-87H9 on c... 25.0 3549
gb|AC116618.4| Homo sapiens BAC clone RP11-98L17 from 4, comp... 25.0 3549
emb|CR786580.6| Human DNA sequence from clone RP11-764K9 on c... 25.0 3549
emb|AL591385.7| Human DNA sequence from clone RP11-391M20 on ... 25.0 3549
emb|AL445925.19| Human DNA sequence from clone RP11-403A15 on... 25.0 3549
emb|AL592183.10| Human DNA sequence from clone RP11-297D8 on ... 25.0 3549
ref|XM_787798.2| PREDICTED: Strongylocentrotus purpuratus sim... 24.3 6861
ref|XM_001201471.1| PREDICTED: Strongylocentrotus purpuratus ... 24.3 6861
gb|AC195625.1| Pan troglodytes BAC clone CH251-895L14 from ch... 23.9 7711
gb|AC175749.2| Pan troglodytes BAC clone CH251-1124N9 from ch... 23.9 7711



Download subject sequence spanning the                                    HSP Pan troglodytes BAC clone CH251-444E8 from chromosome 7, complete sequence Length=155150
Score = 25.8 bits (55), Expect = 1930, Method: Composition-based stats. Identities = 8/13 (61%), Positives = 11/13 (84%), Gaps = 0/13 (0%) Frame = -2

Query 1 ____ CHARLESDARWIN 13
_____________CH RLE D+++IN
Sbjct 145762 CHVRLEQDSKYIN 145724


gb|AC093749.3| Download subject sequence spanning the                                    HSP Homo sapiens BAC clone RP11-30B7 from 4, complete sequence Length=163102 Score = 25.8 bits (55), Expect = 1930, Method: Composition-based stats.
Identities = 8/13 (61%), Positives = 11/13 (84%), Gaps = 0/13 (0%) Frame = -3

Query 1 ___ CHARLESDARWIN 13
____________CH RLE D+++IN
Sbjct 31925 CHVRLEQDSKYIN 31887

10 simple ways to honor Charlie D (aka Darwin)

If you do not know, Thursday is a big day - Darwin Day 2009. A global celebration in honor of the 200th anniversary of Charles Darwin's birth. Today I am making a suggestion of 10 simple things you can do to honor Darwin:
  1. Read one of his books OTHER than Origin of Species (see Darwin online for some there). My favorite is the Voyage of the Beagle but there are many others.
  2. Stop using the terms Darwinism and Darwinian evolution (see Safina for more on this - I thought this article was a bit of overkill but still has some important points).
  3. Vote against anyone who says Intelligent Design should be taught in science class or that you should "teach the controversy." Or at least endorse right thinking candidates.
  4. Contribute to evolution education in some way - teaching, writing a book, releasing teaching materials, donate to a museum (e.g., California Academy) or other organization (e.g., NCSE) or even the cool HMS Beagle Project. Just help educate the world about the science of evolution.
  5. Attend some Darwin Day celebration(s).
  6. Get a cool evolution tattoo (see Zimmer for more) or display your support in some outward way.
  7. Support the National Science Foundation (if you are in the US) as they are the strongest supporters of Evolution related research.
  8. Name your kid or pet or boat or city after him.
  9. Visit the Galapagos or at least check out the Darwin Station online.(see pics below ...)
  10. Insert your own here .....

Open Evolution: Kudos to SMBE for creating a new Open Access publication - Genome Biology and Evolution

Another sign that Open Access is spreading.  SMBE, which publishes the journal MBE (Molecular Biology and Evolution) is announcing the creation of a new journal - Genome Biology and Evolution (GBE).  And happily it will be an Open Access journal being published by Oxford under the Oxford Open system (not quite a full creative commons license like PLoS journals, but pretty good).  I am VERY pleased to see this, especially since I quit the Editorial Board at MBE mostly because they were not moving fast enough to Open Access for me.  Kudos to SMBE, Bill Martin (the new Editor in Chief of GBE) and all the folks at Oxford for doing a good thing.

Please - bash my latest paper - for the benefit of humanity











My lab has a new paper that just came out on the sequencing and analysis of the genome of a pretty cool (or hot actually) bacterium, Thermomicrobium roseum, which was isolated from a Toadstool Spring, an alkaline siliceous hotspring in Yellowstone National Park. This paper is from a grant we had when I was at TIGR as part of the "Assembling the Tree of Life" program at NSF. Our grant was focused on generating genome sequences from phyla of bacteria for which no genomes were available.

At the time this species was a representative of a phylum that had no genomes. After we started sequencing, the phylum was dissolved, but never mind that for now. We report what I think are some very interesting things in the paper. Among them:
  • We report the first example of a plasmid that encodes all the genes needed for chemotaxis including all the genes for making a flagellum. Given that they are on a plasmid this suggests that motility could be easily transfered between species.
  • We report experimental work and genome analysis that helps understand the novel membrane and cell wall structure in this species.
  • This is the first thermophile known to oxidize carbon monoxide
But I am not writing per se about the things I like about our paper. I am instead asking people out there to find things wrong with our paper. Why am I doing this? Because this paper is part of a broader experiment in publishing in that it is in PLoS One. And one of the main benefits of PLoS One is the features that allows commenting on publications. I personally believe such features are part of the future of scientific publication. But it is currently unclear just how effectively such commenting features are used (note Euan Addie is doing a survey about comments on PLoS One papers here).

So I am offering up my paper as a case study. If you comment and ask questions or make critiques, I will try to respond. And if you think something in our paper is wrong or weird, please say so. If you think something in our paper is supported by other work we do not cite, please say this too. If you have anything useful to say, please make comments.

How do you do this?
  • Go to the paper at the PLoS One Web Site.
  • In the upper right click on "Login" if you have an account or "Create account" if you do not.
  • Return to the paper once you are logged in
  • Find some part of the text you want to comment on
  • Highlight that text and click over on the right "Add a note" or "Make a comment"
  • Fire away.

Harold Varmus on Science Friday

There was a very interesting interview on Science Friday last week.  The discussion was with Harold Varmus (see Science Friday Archives: Harold Varmus).
In the interview, Varmus discussed his new book, his role as an advisor to Obama, and some issues relating to Open Access.  I found his comments to be very interesting and insightful and it is worth listening to.